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A: [[Rare-Metal-Worker|rareMetalWorker]] is the program that generates summary statistics for individual studies. It generates both single variant association results and covariance matrices of score statistics. It enables analysis of familial data, population data, unrelated individuals and sample with cryptic relatedness.  [[RareMETAL|rareMETAL]] takes the summary statistics generated by raerMetalWorker to perform both single variant and gene-level association analysis.