Changes

== Approach ==

== Approach ==

The key idea behind meta-analysis with RAREMETAL is that various gene-level test statistics can be reconstructed from single variant score statistics and that, when the linkage disequilibrium relationships between variants are known, the distribution of these gene-level statistics can be derived and used to evaluate signifi-cance. Single variant statistics are calculated using the Cochran-Mantel-Haenszel method. Our method has been published in [http://arxiv.org/abs/1305.1318 Liu et. al] in Nature Genetics. Please go to [http://genome.sph.umich.edu/wiki/RAREMETAL_method '''method'''] for details.

The key idea behind meta-analysis with RAREMETAL is that various gene-level test statistics can be reconstructed from single variant score statistics and that, when the linkage disequilibrium relationships between variants are known, the distribution of these gene-level statistics can be derived and used to evaluate signifi-cance. Single variant statistics are calculated using the Cochran-Mantel-Haenszel method. Our method has been published in [http://arxiv.org/abs/1305.1318 '''Liu et. al'''] in Nature Genetics. Please go to [http://genome.sph.umich.edu/wiki/RAREMETAL_method '''method'''] for details.

== Download and Installation ==

== Download and Installation ==