Changes

The key idea behind meta-analysis with RAREMETAL is that various gene-level test statistics can be reconstructed from single variant score statistics and that, when the linkage disequilibrium relationships between variants are known, the distribution of these gene-level statistics can be derived and used to evaluate signifi-cance. Single variant statistics are calculated using the Cochran-Mantel-Haenszel method. Our method has been published in [http://arxivwww.orgnature.com/ng/journal/v46/n2/abs/1305ng.2852.1318 html '''Liu et. al'''] in Nature Genetics. Please go to [http://genome.sph.umich.edu/wiki/RAREMETAL_method '''method'''] for details.