# Changes

In this model, $\gamma_ibeta_i$ is to measure the additive genetic effect of the $i^{th}$ variant. As usual, the score statistic for testing $H_0:\gamma_i=0$ is:
$U_i=(\mathbf{G_i}-\mathbf{\bar{G_i}} )^T \hat{\boldsymbol{\Omega}}^{-1}(\mathbf{y}-\mathbf{X}\boldsymbol{\beta})$