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Single variant meta-analysis score statistic can be reconstructed from score statistics and their variances generate by each study, assuming unrelated samples across studies, and is written
Single variant meta-analysis score statistic can be reconstructed from score statistics and their variances generate by each study, assuming unrelated samples across studies, and is written
<math>T_i=\sum_{k=1}^S {U_{i,k}}\bigg/\sqrt{\sum_{k=1}^S{V_{ii,k}}}</math>
<math>T_i=\sum_{k=1}^S {U_{i,k}}\bigg/\sqrt{\sum_{k=1}^S{V_{ii,k}}}</math>
The score statistics asymptotically follows standard normal distribution, or <math>T\sim\mathbf{N}(0,1)</math>
===BURDEN META ANALYSIS===
===BURDEN META ANALYSIS===
