From Genome Analysis Wiki
Jump to navigationJump to search
60 bytes added
, 21:11, 8 April 2014
Line 16: |
Line 16: |
| | | |
| ===SINGLE VARIANT META ANALYSIS=== | | ===SINGLE VARIANT META ANALYSIS=== |
− | Single variant meta-analysis score statistic can be reconstructed from score statistics and their variances generate by each study, assuming unrelated samples across studies, and is written | + | Single variant meta-analysis score statistic can be reconstructed from score statistics and their variances generate by each study, assuming unrelated samples across studies, and asymptotically follows standard normal distribution |
− | <math>T_i=\sum_{k=1}^S {U_{i,k}}\bigg/\sqrt{\sum_{k=1}^S{V_{ii,k}}}</math>. | + | <math>T_i=\sum_{k=1}^S {U_{i,k}}\bigg/\sqrt{\sum_{k=1}^S{V_{ii,k}}} \sim\mathbf{N}(0,1)</math> |
| | | |
| This score statistics asymptotically follows standard normal distribution, or <math>T\sim\mathbf{N}(0,1)</math> | | This score statistics asymptotically follows standard normal distribution, or <math>T\sim\mathbf{N}(0,1)</math> |