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RAREMETAL METHOD

203 bytes added, 21:25, 8 April 2014
SINGLE VARIANT META ANALYSIS
===SINGLE VARIANT META ANALYSIS===
Single variant meta-analysis score statistic can be reconstructed from score statistics and their variances generate by each study, assuming that samples are unrelated across studies, and asymptotically follows standard normal distribution . Define meta-analysis score statistics as
<math>T_iU_{meta,i}=\sum_{k=1}^S {U_{i,k}}</math> and its variance <math>\sum_{k=1}^S{V_{ii,k}}</math> Then the score test statistics <math>T_{meta,i}</math> asymptotically follows standard normal distribution  <math>T_{meta,i}=\sum_{k=1}^S {U_{i,k}}\bigg/\sqrt{\sum_{k=1}^S{V_{ii,k}}} \sim\mathbf{N}(0,1)</math>
===BURDEN META ANALYSIS===
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