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===SINGLE VARIANT META ANALYSIS===
===SINGLE VARIANT META ANALYSIS===
Single variant meta-analysis score statistic can be reconstructed from score statistics and their variances generate by each study, assuming that samples are unrelated across studies, and asymptotically follows standard normal distribution
Single variant meta-analysis score statistic can be reconstructed from score statistics and their variances generate by each study, assuming that samples are unrelated across studies. Define meta-analysis score statistics as
<math>T_i=\sum_{k=1}^S {U_{i,k}}\bigg/\sqrt{\sum_{k=1}^S{V_{ii,k}}} \sim\mathbf{N}(0,1)</math>
<math>U_{meta,i}=\sum_{k=1}^S {U_{i,k}}</math>
and its variance
<math>\sum_{k=1}^S{V_{ii,k}}</math>
Then the score test statistics <math>T_{meta,i}</math> asymptotically follows standard normal distribution
<math>T_{meta,i}=\sum_{k=1}^S {U_{i,k}}\bigg/\sqrt{\sum_{k=1}^S{V_{ii,k}}} \sim\mathbf{N}(0,1)</math>
===BURDEN META ANALYSIS===
===BURDEN META ANALYSIS===
