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RAREMETAL METHOD

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SINGLE VARIANT META ANALYSIS
Single variant meta-analysis score statistic can be reconstructed from score statistics and their variances generate by each study, assuming that samples are unrelated across studies. Define meta-analysis score statistics as
<math>U_{meta,imeta_i}=\sum_{k=1}^S {U_{i,k}}</math>
and its variance
<math>V_{meta,imeta_i}=\sum_{k=1}^S{V_{ii,k}}</math>
Then the score test statistics for the <math>i^{th}</math> variant <math>T_{meta,imeta_i}</math> asymptotically follows standard normal distribution
<math>T_{meta,imeta_i}=U_{meta,imeta_i}\bigg/\sqrt{V_{meta,imeta_i}}=\sum_{k=1}^S {U_{i,k}}\bigg/\sqrt{\sum_{k=1}^S{V_{ii,k}}} \sim\mathbf{N}(0,1)</math>
===BURDEN META ANALYSIS===
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