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, 23:31, 8 April 2014
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| ===BURDEN META ANALYSIS=== | | ===BURDEN META ANALYSIS=== |
− | Once single variant meta analysis statistics are constructed, burden test score statistic can be easily reconstructed as | + | |
| + | Burden test has been shown to be powerful detecting a group of rare variants that are unidirectional in effects. Once single variant meta analysis statistics are constructed, burden test score statistic can be easily reconstructed as |
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| <math>T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)</math>. | | <math>T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)</math>. |