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RAREMETAL METHOD

114 bytes added, 23:31, 8 April 2014
BURDEN META ANALYSIS
===BURDEN META ANALYSIS===
 Burden test has been shown to be powerful detecting a group of rare variants that are unidirectional in effects. Once single variant meta analysis statistics are constructed, burden test score statistic can be easily reconstructed as
<math>T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)</math>.
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