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RAREMETAL METHOD

, 23:45, 8 April 2014
VT META ANALYSIS
$T_{VT}=\max(T_{b\left(f_1\right)},T_{b\left(f_2\right)},\dots,T_{b\left(f_m\right)})$
where the burden test statistic under each any allele frequency threshold can be constructed from single variant meta-analysis statistics
$T_{b\left(f_j\right)}=\boldsymbol{\phi}_{f_j}^\mathbf{T}\sum_{i=1}^n{\mathbf{U_i}}\bigg/\sqrt{\boldsymbol{\phi}_{f_j}^\mathbf{T}\left(\sum_{i=1}^n{\mathbf{V_i}}\right)\boldsymbol{\phi}_{f_j}}$

where $j$ represents any allele frequency in a group of rare variants.
===SKAT META ANALYSIS===
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