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where the burden test statistic under any allele frequency threshold can be constructed from single variant meta-analysis statistics using
where the burden test statistic under any allele frequency threshold can be constructed from single variant meta-analysis statistics using
<math>T_{b\left(f_j\right)}=\boldsymbol{\phi}_{f_j}^\mathbf{T}\sum_{i=1}^n{\mathbf{U_i}}\bigg/\sqrt{\boldsymbol{\phi}_{f_j}^\mathbf{T}\left(\sum_{i=1}^n{\mathbf{V_i}}\right)\boldsymbol{\phi}_{f_j}} </math>is a vector of 0 and 1, indicating if a variant is included in the analysis using frequency threshold <mat>f_i </math>
<math>T_{b\left(f_j\right)}=\boldsymbol{\phi}_{f_j}^\mathbf{T}\mathbf{U_{meta}}\bigg/\sqrt{\boldsymbol{\phi}_{f_j}^\mathbf{T}\mathbf{V_{meta}}\boldsymbol{\phi}_{f_j}} </math>is a vector of 0 and 1, indicating if a variant is included in the analysis using frequency threshold <mat>f_i </math>
where <math>j</math> represents any allele frequency in a group of rare variants, <math>\boldsymbol{\phi}_{f_j}</math> is a
where <math>j</math> represents any allele frequency in a group of rare variants, <math>\boldsymbol{\phi}_{f_j}</math> is a
