# Changes

$T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)$, where $\mathbf{U_{meta}} = (U_{meta_1},U_{meta_2},...,U_{meta_m})$, representing a vector of single variant meta-analysis scores of $m$ variants in a gene.