# Changes

$T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)$,
where $\mathbf{U_{meta}} = (U_{meta_1},U_{meta_2},...,U_{meta_m})and \mathbf{V_meta}=cov(\mathbf{U_{meta}}$, representing a vector of single variant meta-analysis scores of $m$ variants in a geneand the covariance matrix of the scores across $m$ variants.