Changes

This workshop was prepared for the 51st Mammalian Genetics Short Course, at the Jackson Laboratory in Bar Harbor. It illustrates several simple analyses of genetic association studies (we are necessarily limited by time!).

This workshop was prepared for the 51st Mammalian Genetics Short Course, at the Jackson Laboratory in Bar Harbor. It illustrates several simple analyses of genetic association studies (we are necessarily limited by time!).

= Glusose Data Set =

= Glucose Data Set =

This example examines evidence for association between fasting glucose levels and genetic markers in the [http://www.sph.umich.edu/csg/abecasis/publications/18521185.html G6PC2] (chr. 2), GCK (chr. 7) and [http://www.sph.umich.edu/csg/abecasis/publications/19060907.html MTNR1B] (chr. 11) regions. It uses results from 3 genomewide association studies: [http://www.sph.umich.edu/csg/abecasis/publications/17463248.html FUSION], [http://www.sph.umich.edu/csg/abecasis/publications/PLOS-Obesity-Scan.html SardiNIA] and [http://www.ncbi.nlm.nih.gov/pubmed/17463246 DGI]. Genetic variants in the three loci impact fasting glucose levels and, in the case of MTRN1B, also impact the risk of type 2 diabetes.  

This example examines evidence for association between fasting glucose levels and genetic markers in the [http://www.sph.umich.edu/csg/abecasis/publications/18521185.html G6PC2] (chr. 2), GCK (chr. 7) and [http://www.sph.umich.edu/csg/abecasis/publications/19060907.html MTNR1B] (chr. 11) regions. It uses results from 3 genomewide association studies: [http://www.sph.umich.edu/csg/abecasis/publications/17463248.html FUSION], [http://www.sph.umich.edu/csg/abecasis/publications/PLOS-Obesity-Scan.html SardiNIA] and [http://www.ncbi.nlm.nih.gov/pubmed/17463246 DGI]. Genetic variants in the three loci impact fasting glucose levels and, in the case of MTRN1B, also impact the risk of type 2 diabetes.