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Revision as of 04:30, 26 October 2010
, 04:30, 26 October 2010→Overview
== Overview ==
== Overview ==
This lecture introduces the problem of population stratification in the context of genetic association studies. It also discusses three possible strategies for handling population structure, specifically:
This lecture introduces the problem of population stratification in the context of genetic association studies. It also discusses introduces several possible strategies for detecting and handling population structure, specifically:
* Using family based association tests, such as the TDT.
* Q-Q plots as a diagnostic tool in genetic association studies.
* Controling the overall inflation of test statistics, using the genomic control method.
* Using family based association tests, such as the TDT, to avoid spurious association even when a single marker is tested.
* Using genotype based matching approaches.
* Using the genomic control method to controling the overall inflation of test statistics, when many markers are tested.
* Using genotype based matching approaches to model population structure more explicitly.
== Lecture Notes ==
== Lecture Notes ==
*Methods for Inferring Population Structure
*Methods for Inferring Population Structure
**Pritchard, Stephens and Donnelly, 2000. Genetics 155: 945-959
**Pritchard, Stephens and Donnelly, 2000. Genetics 155: 945-959
* Principal Components Analysis
** Price et al (2006) Nature Genetics 38:904-909
*Transmission Disequilibrium Tests
*Transmission Disequilibrium Tests
**Spielman et al (1993) Am J Hum Genet 52:506-16 (trios)
**Spielman et al (1993) Am J Hum Genet 52:506-16 (trios)
**Curtis (1997) Ann Hum Genet 61:319-33 (sibling pairs)
**Curtis (1997) Ann Hum Genet 61:319-33 (sibling pairs)
