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Revision as of 03:00, 22 February 2010
, 03:00, 22 February 2010Created page with ' == Overview == This lecture introduces the problem of population stratification in the context of genetic association studies. It also discusses three possible strategies for h…'
== Overview ==
This lecture introduces the problem of population stratification in the context of genetic association studies. It also discusses three possible strategies for handling population structure, specifically:
* Using family based association tests, such as the TDT.
* Controling the overall inflation of test statistics, using the genomic control method.
* Using genotype based matching approaches.
== Lecture Notes ==
[[Media:666.13.pdf|Slides in PDF Format]]
== Recommended Reading ==
*Genomic Control for Association Studies
**Devlin and Roeder (1999) Biometrics 55:997-1004
**Pritchard and Rosenberg (1999) Am J Hum Genet 65:220-228
*Methods for Inferring Population Structure
**Pritchard, Stephens and Donnelly, 2000. Genetics 155: 945-959
*Transmission Disequilibrium Tests
**Spielman et al (1993) Am J Hum Genet 52:506-16 (trios)
**Curtis (1997) Ann Hum Genet 61:319-33 (sibling pairs)
