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# '''Where are the genetic variants that influence a trait?''' These types of analysis try to assign a specific chromosomal location to the variants that influence the trait. Traditionally, this step relied on linkage analysis but association analysis and related approaches are now more common.
# '''Where are the genetic variants that influence a trait?''' These types of analysis try to assign a specific chromosomal location to the variants that influence the trait. Traditionally, this step relied on linkage analysis but association analysis and related approaches are now more common.
# '''What are the specific variants that influence a trait?''' This is, ultimately, the most interesting question but is often the hardest questions to answer. It requires exhaustive measurement of DNA variation in a region of interest and, often, comparison of results across different populations and follow-up laboratory experiments.
# '''What are the specific variants that influence a trait?''' This is, ultimately, the most interesting question but is often the hardest questions to answer. It requires exhaustive measurement of DNA variation in a region of interest and, often, comparison of results across different populations and follow-up laboratory experiments.
== Recommended Reading ==
If you need a refresher or introduction to molecular genetics, I recommend:
Human Molecular Genetics by ''Tom Strachan and Andrew Read'' [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=hmg Web Edition at NCBI]
Lander and Schork (1994) "Genetic Dissection of Complex Traits" ''Science'' '''265''':2037-48 [http://www.sciencemag.org/cgi/rapidpdf/265/5181/2037.pdf PDF at Science Magazine]
== Slides ==
== Slides ==
[[Media:666.01.pdf|Slides in PDF Format]]
[[Media:666.01.pdf|Slides in PDF Format]]
