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Revision as of 03:08, 11 November 2010
, 03:08, 11 November 2010Created page with '== Outline == This lecture introduces Neil Risch's Maximum Lod Score (MLS) test for linkage and its refinement using Peter Holman's possible triangle constraint. == Slides == …'
== Outline ==
This lecture introduces Neil Risch's Maximum Lod Score (MLS) test for linkage and its refinement using Peter Holman's possible triangle constraint.
== Slides ==
[[666.2010.02.pdf|Slides in PDF Format]]
== Recommended Reading ==
Risch (1990) Linkage Strategies for Genetically Complex Traits. III. The Effect of Marker Polymorphism on Analysis of Affected Relative Pairs. ''Am J Hum Genet'' '''46''':242-253
Risch (1990) Linkage strategies for genetically complex traits. I. Multi-locus models. ''Am J Hum Genet'' '''46''':222-228
Holmans (1993) Asymptotic Properties of �Affected-Sib-Pair Linkage Analysis. ''Am J Hum Genet'' '''52''':362-374
This lecture introduces Neil Risch's Maximum Lod Score (MLS) test for linkage and its refinement using Peter Holman's possible triangle constraint.
== Slides ==
[[666.2010.02.pdf|Slides in PDF Format]]
== Recommended Reading ==
Risch (1990) Linkage Strategies for Genetically Complex Traits. III. The Effect of Marker Polymorphism on Analysis of Affected Relative Pairs. ''Am J Hum Genet'' '''46''':242-253
Risch (1990) Linkage strategies for genetically complex traits. I. Multi-locus models. ''Am J Hum Genet'' '''46''':222-228
Holmans (1993) Asymptotic Properties of �Affected-Sib-Pair Linkage Analysis. ''Am J Hum Genet'' '''52''':362-374
