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This lecture introduces simple linkage tests in the context of affected sibling pairs. One test, originally described by Bishop and Williamson (1990) focuses on identity-by-state sharing. A more refined test, introduced by Risch (1990), models IBD information using a likelihood approach.
This lecture introduces simple linkage tests in the context of affected sibling pairs. One test, originally described by Bishop and Williamson (1990) focuses on identity-by-state sharing. A more refined test, introduced by Risch (1990), models IBD information using a likelihood approach.
== Lecture Notes ==
== Lecture Notes ==
[[Media:666.13.pdf|Slides in PDF Format]]
[[Media:666.14.pdf|Slides in PDF Format]]
== Recommended Reading ==
== Recommended Reading ==
Bishop DT and Williamson JA (1990)''Am J Hum Genet'' '''46''':254-265
Bishop DT and Williamson JA (1990) ''Am J Hum Genet'' '''46''':254-265
Risch (1990) ''Am J Hum Genet'' '''46''':242-253
Risch (1990) ''Am J Hum Genet'' '''46''':242-253
