Difference between revisions of "Biostatistics 666: Linkage Tests for Pairs of Individuals"
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Revision as of 07:15, 23 March 2010
Overview
This lecture introduces simple linkage tests in the context of affected sibling pairs. One test, originally described by Bishop and Williamson (1990) focuses on identity-by-state sharing. A more refined test, introduced by Risch (1990), models IBD information using a likelihood approach.
Lecture Notes
Recommended Reading
Bishop DT and Williamson JA (1990)Am J Hum Genet 46:254-265
Risch (1990) Linkage Strategies for Genetically Complex Traits. III.�The Effect of Marker Polymorphism on Analysis of Affected Relative Pairs. Am J Hum Genet 46:242-253
