Biostatistics 666: Linkage Tests for Pairs of Individuals

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Overview

This lecture introduces simple linkage tests in the context of affected sibling pairs. One test, originally described by Bishop and Williamson (1990) focuses on identity-by-state sharing. A more refined test, introduced by Risch (1990), models IBD information using a likelihood approach.

Lecture Notes

Slides in PDF Format

Recommended Reading

Bishop DT and Williamson JA (1990)Am J Hum Genet 46:254-265

Risch (1990) Linkage Strategies for Genetically Complex Traits. III.�The Effect of Marker Polymorphism on Analysis of Affected Relative Pairs. Am J Hum Genet 46:242-253

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