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[[File:EMADS_thumb5.png|thumb|340px|right]]

[[File:EMADS_thumb5.png|thumb|340px|right]]

Welcome! This is an informational page devoted to the EMADS consortium, the exome meta-analysis of drinking and smoking.

Welcome! This is an informational page devoted to the EMADS consortium, the exome meta-analysis of drinking and smoking.

We have a primary teleconference on a monthly basis. Senior and junior investigators from each site contribute to consortium planning.

We have a primary teleconference on a monthly basis. Senior and junior investigators from each site contribute to consortium planning.

'''The next primary call will take place on June 21 2013 at 11am EDT (4pm BST).'''

'''The next primary call will take place on August 16 2013 at 11am EDT (4pm BST).'''

 

 

'''The next analyst call will take place on June 6 2013 at 11am EDT (4pm BST)'''

== Analysis Projects  ==

== Analysis Projects  ==

# The senior investigators who strongly led/oversaw the writing and/or analysis of the paper, including a subset that are co-corresponding authors (usually 6 or fewer).

# The senior investigators who strongly led/oversaw the writing and/or analysis of the paper, including a subset that are co-corresponding authors (usually 6 or fewer).

Protocol to consider proposals for (1) analysis of EMADS summary statistics and (2) requests for site investigators to perform additional analysis.

== Guidelines for Handling Proposals for Additional Analysis of EMADS Data ==

 

== Proposal Management ==

In consultation with Goncalo, Scott will receive and coordinate proposals for discussion during regular conference calls.

In consultation with Goncalo, Scott will receive and coordinate proposals for discussion during regular conference calls.

=== Categories of Proposals ===

=== Categories of Proposals ===

==== Secondary Analyses of Existing Summary Data ====

==== Secondary Analyses of Existing Summary Data ====

At the time of this writing (5/7/2013), all summary statistics will be protected on University of Michigan servers, and curated by Scott and Goncalo. Proposals that call for analysis of existing data will be discussed by local site principal investigators. If approved, these proposals will be granted to selected portions of the summary statistics. Any manuscript generated from these secondary analyses must not be submitted for publication until the primary EMADS manuscript has been accepted for publication.

At the time of this writing (5/7/2013), all summary statistics will be protected on University of Michigan servers, and curated by Scott and Goncalo. Proposals that call for analysis of existing data will be discussed by local site principal investigators. Note that some principal investigators may have to obtain permission from committees overseeing their study before sharing summary statistics from that study (e.g., for very large and/or complex cohorts). If approved, these proposals will be granted access to selected portions of the summary statistics. Any manuscript generated from these secondary analyses must not be submitted for publication until the primary EMADS manuscript has been accepted for publication.

 

The EMADS consortium should be listed as an author, if possible, in any resulting publication. If listing a consortium is not possible, for example due to journal guidelines, then individual EMADS investigators may be listed. Further, depending on the level of involvement from EMADS members in facilitating fulfillment of the proposal's aims, individual investigators may be named as well.

In general, we expect most if not all proposals for secondary analysis of existing summary data to be approved.

In general, we expect most if not all proposals for secondary analysis of existing summary data to be approved.

Proposals that request local sites to perform additional analysis will be more difficult to implement. In the end, such proposals will be "at the mercy" of local sites, who may or may not agree to conduct the proposed analyses. Such proposals can be discussed on conference calls and local sites may volunteer to participate.

Proposals that request local sites to perform additional analysis will be more difficult to implement. In the end, such proposals will be "at the mercy" of local sites, who may or may not agree to conduct the proposed analyses. Such proposals can be discussed on conference calls and local sites may volunteer to participate.

The EMADS consortium will be listed as an author in any resulting publication, and existing EMADS authorship guidelines will be integrated or adopted.

The EMADS consortium should be listed as an author, if possible, in any resulting publication. If listing a consortium is not possible, for example due to journal guidelines, then individual EMADS investigators may be listed. Further, depending on the level of involvement from EMADS members in facilitating fulfillment of the proposal's aims, individual investigators may be named as well.

 

Summary statistics of genetic variants are not truly de-identified, as they can still be used by a sufficiently sophisticated and motivated person to re-identify individuals. This concern must be taken very seriously, and any proposal to use EMADS data, even if only summary statistics, must have a plan to assure the safety and security of the data, protect against its re-release, and must guarantee that there will be no attempt to re-identify the data.

=== Submitting Proposals ===

=== Submitting Proposals ===