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* Executable can be downloaded in the following:
* Executable can be downloaded in the following:
[[Media:Famrvtest.linux.executable.tgz |Executable for '''LINUX''']]
[[Media:Famrvtest.2.4.linux.executable.tgz |Executable for '''LINUX''']]
=== How to Compile ===
=== How to Compile ===
* Save it to your local path and decompress using the following command:
* Save it to your local path and decompress using the following command:
tar xvzf LINUX_famrvtest.2.3.tgz
tar xvzf LINUX_famrvtest.2.4.tgz
* Go to promp>famrvtest and type the following command to compile:
* Go to promp>famrvtest and type the following command to compile:
make
make
=== PED and DAT Files ===
=== PED and DAT Files ===
* When PED file has genotypes saved, there is no need for a VCF file as input.
* When PED file has genotypes saved, there is no need for a VCF file as input.
* '''famrvtest''' takes PED/DAT file in [http://www.sph.umich.edu/csg/abecasis/Merlin/index.html|'''Merlin'''] format. Please refer to [http://www.sph.umich.edu/csg/abecasis/merlin/tour/input_files.html PED/DAT format description] for details.
* '''famrvtest''' takes PED/DAT file in [http://www.sph.umich.edu/csg/abecasis/Merlin/index.html '''Merlin'''] format. Please refer to [http://sph.umich.edu/csg/abecasis/merlin/tour/input_files.html PED/DAT format description] for details.
* An example PED file is in the following:
* An example PED file is in the following:
1 1 0 0 1 1.5 1 23 A A A A A A A A A A
1 1 0 0 1 1.5 1 23 A A A A A A A A A A
GROUP_ID MARKER1_ID MARKER2_ID MARKER3_ID ...
GROUP_ID MARKER1_ID MARKER2_ID MARKER3_ID ...
* MARKER_ID must be in the following format:
* MARKER_ID must be in the following format:
CHR:POS_ALLELE1/ALLELE2
CHR:POS:ALLELE1:ALLELE2
* An example group file is:
* An example group file is:
PLEKHN1 1:901922_G/A 1:901923_C/A 1:902088_G/A 1:902128_C/T 1:902133_C/G 1:902176_C/T 1:905669_C/G
PLEKHN1 1:901922:G:A 1:901923:C:A 1:902088:G:A 1:902128:C:T 1:902133:C:G 1:902176:C:T 1:905669:C:G
HES4 1:934735_A/C 1:934770_G/A 1:934801_C/T 1:935085_G/A 1:935089_C/G
HES4 1:934735:A:C 1:934770:G:A 1:934801:C:T 1:935085:G:A 1:935089:C:G
* '''Version 2.4 and later allow variants from different chromosomes to be grouped for testing. This might be useful for pathway analysis.'''
* '''Note: any variants that have different alleles from listed in group file will be excluded from gene-level tests.'''
* '''Note: any variants that have different alleles from listed in group file will be excluded from gene-level tests.'''
* Uploaded new source code package for version2.2, with updated makefiles. (8/4/14)
* Uploaded new source code package for version2.2, with updated makefiles. (8/4/14)
* Released version 2.3. Fixed a bug which causes compiling error (not finding the correct makefile). (8/20/14)
* Released version 2.3. Fixed a bug which causes compiling error (not finding the correct makefile). (8/20/14)
* Released version 2.4. Enable analyzing pathways where variants from different chromosomes can be grouped. (9/27/2014)
