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, 11:34, 26 September 2013
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| **P(non-reference heterozygote) = 0.01 * 2/3 | | **P(non-reference heterozygote) = 0.01 * 2/3 |
| **P(non-reference homozygote) = 0.01 * 1/3 | | **P(non-reference homozygote) = 0.01 * 1/3 |
− | *Two options of mutation model: | + | *Mutation model: Transitions (C <-> T or A <-> G) accounts for most variants, while transversions account for minority of variants |
− | **Transitions (C <-> T or A <-> G) accounts for most variants, while transversions account for minority of variants
| + | **transition has 2/3 probability |
− | **Uniform prior for transition to transversion ratio (1:1) | + | **each transversion has 1/6 probability |
| + | |
| + | *'''New implementation''': Alternative mutation model with uniform (uninformative) prior for transition to transversion ratio |
| + | **updated by Yancy Lo, 9/24/2012 |
| + | **each mutation has a 1/3 probability |
| + | **add --uniformTsTv in command line to enable this alternative mutation model |
| + | **download glfSingle with this new implementation here: [[File:Generic-glfSingle-2013-09-25.tar.gz]] |
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| == Download == | | == Download == |