Changes

Mandatory input for each input file;

Mandatory input for each input file;

• Marker name

* Marker name

• Reference allele (also known as the ‘effect allele’) and the non-reference allele

* Reference allele (also known as the ‘effect allele’) and the non-reference allele

• P-value

* P-value

• Weight (sample size or standard error)

* Weight (sample size or standard error)

• Direction of effect relative to reference allele

* Direction of effect relative to reference allele

Tables must have column headers that specify where the mandatory input can be found.  The default name for the Marker column is ‘MARKER’, but can be changed to match the relevant input file column with the following command;

Tables must have column headers that specify where the mandatory input can be found.  The default name for the Marker column is ‘MARKER’, but can be changed to match the relevant input file column with the following command;

METAL can also evaluate the evidence for heterogeneity.  When you do this, METAL will do a second pass of analysis to decide whether observed effect sizes (or test statistics) are homogeneous across samples.  This will result in a test statistic (with n-1) degrees of freedom for n samples.

METAL can also evaluate the evidence for heterogeneity.  When you do this, METAL will do a second pass of analysis to decide whether observed effect sizes (or test statistics) are homogeneous across samples.  This will result in a test statistic (with n-1) degrees of freedom for n samples.

ANALYZE HETEROGENEITY

==ANALYZE HETEROGENEITY==

 

 

 

Example 1; Strand flips required

Example 1; Strand flips required