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The '''Informatics Resource Core''' provides advice to participating studies, sequencing centers and staff at the National Institutes of Health on the handling, processing and interpretation of large scale sequence data. The IRC will also be responsible for producing a joint analysis of available sequence data and aiding study investigators with informatics challenges when needed, particularly for cross study analyses. Long-term, a major goal of the Informatics Resource Center is to make study results easily accessible to a broad range of scientists.

The '''Informatics Resource Core''' provides advice to studies participating in a landmark NHLBI initiative to sequence 20,000 human genomes in 2015, as well as to sequencing centers and staff at the National Institutes of Health on the handling, processing and interpretation of large scale sequence data. The IRC will also be responsible for producing a joint analysis of available sequence data and aiding study investigators with informatics challenges when needed, particularly for cross study analyses. Long-term, a major goal of the Informatics Resource Center is to make study results easily accessible to a broad range of scientists.

== Key Individuals ==

== Key Individuals ==

== Key Technologies ==

== Key Technologies ==

To learn about some of the tools we have developed and will be using in this project, read about our [[GotCloud]] pipeline for sequence alignment, variant calling, and filtering, our [[EPACTS]] tool for association analyses with very large data, [[RAREMETAL]] for combining results across studies, [[LocusZoom]] for visualizing study results, [[Minimac]] (now in [[Minimac3|version 3]] and [http://imputationserver.sph.umich.edu/ online]] for genotype imputation, which helps transfer sequence information from sequencing studies to array based studies and [[QPLOT]] and [[VerifyBamId]] for QC of sequence data.

To learn about some of the tools we have developed and will be using in this project, read about our [[GotCloud]] pipeline for sequence alignment, variant calling, and filtering, our [[EPACTS]] tool for association analyses with very large data, [[RAREMETAL]] for combining results across studies, [[LocusZoom]] for visualizing study results, [[Minimac]] (now in [[Minimac3|version 3]] and [http://imputationserver.sph.umich.edu/ online]] for genotype imputation, which helps transfer sequence information from sequencing studies to array based studies and [[QPLOT]] and [[VerifyBamID]] for QC of sequence data.

== Partners ==

== Partners ==

We are thrilled to work with outstanding scientists at the University of Washington, the Broad Institute, the New York Genome Center, Johns Hopkins University, Harvard, the University of Maryland, UCSF, the University of Texas, the University of Mississippi, and the National Institutes of Health among other outstanding teams.

We are thrilled to work with outstanding scientists at the University of Washington, the Broad Institute, the New York Genome Center, Johns Hopkins University, Harvard, the University of Maryland, UCSF, the University of Texas, the University of Mississippi, and the National Institutes of Health among other outstanding teams.