From Genome Analysis Wiki
Jump to navigationJump to search
5 bytes added
, 11:59, 13 March 2014
Line 130: |
Line 130: |
| ==== VC Options ==== | | ==== VC Options ==== |
| * When --vcShared and --vcX are specified, Rare-Metal-Worker knows that you want to fit shared environment and/or chromosome X variance component together with genetic component and non-shared environment. | | * When --vcShared and --vcX are specified, Rare-Metal-Worker knows that you want to fit shared environment and/or chromosome X variance component together with genetic component and non-shared environment. |
− | * When --useCovariates is specified, Rare-Metal-Worker understands covariates should be read from PED file. Covariates are modeled as fixed effects. | + | * When --makeResiduals is specified, Rare-Metal-Worker understands covariates should be read from PED/DAT file. Covariates are modeled as fixed effects. |
| + | |
| ==== Trait Options ==== | | ==== Trait Options ==== |
| * --makeResiduals can be combined with --useCovariates to generate residuals from a simple linear regressions before analysis. If the --inverseNormal option is also used, then the residuals will be quantile normalized before fitting variance component model. | | * --makeResiduals can be combined with --useCovariates to generate residuals from a simple linear regressions before analysis. If the --inverseNormal option is also used, then the residuals will be quantile normalized before fitting variance component model. |