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, 12:03, 13 March 2014
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| ==== Trait Options ==== | | ==== Trait Options ==== |
− | * --makeResiduals can be combined with --useCovariates to generate residuals from a simple linear regressions before analysis. If the --inverseNormal option is also used, then the residuals will be quantile normalized before fitting variance component model. | + | * --makeResiduals tells RMW to adjust the covariates and analyze residuals instead of the original phenotypes. If either --kinGeno or --kinPedigree option is used, then variance component model will be fit based on residuals. If the --inverseNormal option is also used, then the residuals will be quantile normalized before fitting variance component model. |
− | ** An example Command line requesting pre-adjustment for covariates before fitting a variance component follows:
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− | --makeResiduals --inverseNorma
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− | * If --inverseNormal is used WITHOUT --makeResiduals, then trait values are inverse normalized before any model fitting.
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| * --traitName is created for situations when you have many traits saved in your PED and DAT file, but you are interested in one or a few of them. It can read a file ending with .txt with each trait of interest in a separate line, or trait names separated with "/". An example to handle one trait or multiple traits is in the following: | | * --traitName is created for situations when you have many traits saved in your PED and DAT file, but you are interested in one or a few of them. It can read a file ending with .txt with each trait of interest in a separate line, or trait names separated with "/". An example to handle one trait or multiple traits is in the following: |
| --traitName LDL | | --traitName LDL |