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, 13:58, 1 April 2014
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| <math> \mathbf{y}=\mathbf{X}\boldsymbol{\beta_c}+\beta_i(\mathbf{G_i}-\bar{\mathbf{G_i}})+\mathbf{g}+\boldsymbol{\varepsilon} </math>. | | <math> \mathbf{y}=\mathbf{X}\boldsymbol{\beta_c}+\beta_i(\mathbf{G_i}-\bar{\mathbf{G_i}})+\mathbf{g}+\boldsymbol{\varepsilon} </math>. |
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− | Here, [explain the formula]. | + | Here, the quantitive trait for an individual is decided by covariate effects, additive genetic effect from the <math> i^{th} </math> variant and the polygenic background effects together with non-shared environmental effect. |
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| In this model, <math>\beta_i</math> is to measure the additive genetic effect of the <math>i^{th}</math> variant. As usual, the score statistic for testing <math>H_0:\beta_i=0</math> is: | | In this model, <math>\beta_i</math> is to measure the additive genetic effect of the <math>i^{th}</math> variant. As usual, the score statistic for testing <math>H_0:\beta_i=0</math> is: |