From Genome Analysis Wiki
Jump to navigationJump to search
201 bytes added
, 22:50, 7 August 2013
Line 21: |
Line 21: |
| == Brief Description == | | == Brief Description == |
| | | |
− | rareMETAL is a tool for meta-analysis rare variants from genotype arrays and sequencing. rareMETAL can combine summary statistics of individual studies generated by [[Rare-Metal-Worker|rareMetalWorker]]. It provides a convenient approach for both single variant and gene-level meta-analysis of rare variants from various studies, when joint-analysis of raw data from these studies are restricted. | + | '''rareMETAL''' is a computationally efficient tool for meta-analysis of rare variants using sequencing or genotyping array data. '''rareMETAL''' takes summary statistics and LD matrices generated by [[Rare-Metal-Worker|'''rareMetalWorker''']], handles related and unrelated individuals, and supports both single variant and burden meta-analysis. An R-package using the same methodology is [[RareMetals|available]]]. |
| + | |
| + | '''rareMETAL''' is developed by Shuang Feng, Dajiang Liu and Gonçalo Abecasis. Manuscript for this tool is in preparation. Please contact sfengsph at umich dot edu for questions. |
| | | |
| == Approach == | | == Approach == |