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| == Overview == | | == Overview == |
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− | This lecture introduces the problem of population stratification in the context of genetic association studies. It also discusses three possible strategies for handling population structure, specifically: | + | This lecture introduces the problem of population stratification in the context of genetic association studies. It also discusses introduces several possible strategies for detecting and handling population structure, specifically: |
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− | * Using family based association tests, such as the TDT. | + | * Q-Q plots as a diagnostic tool in genetic association studies. |
− | * Controling the overall inflation of test statistics, using the genomic control method. | + | * Using family based association tests, such as the TDT, to avoid spurious association even when a single marker is tested. |
− | * Using genotype based matching approaches. | + | * Using the genomic control method to controling the overall inflation of test statistics, when many markers are tested. |
| + | * Using genotype based matching approaches to model population structure more explicitly. |
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| == Lecture Notes == | | == Lecture Notes == |
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| *Methods for Inferring Population Structure | | *Methods for Inferring Population Structure |
| **Pritchard, Stephens and Donnelly, 2000. Genetics 155: 945-959 | | **Pritchard, Stephens and Donnelly, 2000. Genetics 155: 945-959 |
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| + | * Principal Components Analysis |
| + | ** Price et al (2006) Nature Genetics 38:904-909 |
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| *Transmission Disequilibrium Tests | | *Transmission Disequilibrium Tests |
| **Spielman et al (1993) Am J Hum Genet 52:506-16 (trios) | | **Spielman et al (1993) Am J Hum Genet 52:506-16 (trios) |
| **Curtis (1997) Ann Hum Genet 61:319-33 (sibling pairs) | | **Curtis (1997) Ann Hum Genet 61:319-33 (sibling pairs) |