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Revision as of 11:43, 4 September 2018
, 11:43, 4 September 2018no edit summary
'''One day: Thursday, September 13, 2018, 8:30 am - 3:00 pm ?'''
'''One day: Thursday, September 13, 2018, 8:30 am - 4:00 pm ?'''
Perhaps 4 1/3 total hours of presentations, if lunch is brought in.
Perhaps 5 1/2 total hours of presentations.
= Draft Agenda =
= Draft Agenda =
== Break (30 minutes) ==
== Break (30 minutes) ==
== ENCORE analysis server (15 minutes) ==
== Summary of contract spending to date (20 minutes) ==
''Matthew Flickinger will present this section''
''Denise Bianchi and Goncalo Abecasis will present this section''
* Broad subdivisions: personnel, cloud storage, cloud computing, hardware
* Divided between Task 1 and Task 2
== Improved results from the latest TOPMed imputation panel (20 minutes) ==
''Goncalo Abecasis will present this, unless Lukas Forer is available. Ketian Yu to prepare summaries of imputation quality''
''Goncalo Abecasis will present this, unless Lukas Forrer is available. Ketian to prepare summaries of imputation quality''
[[Media:nhlbi.4761.imputation.accuracy.2018aug31.pptx|'''(slides)''']]
* Principle of operation
* Principle of operation
* Challenges and opportunities from collaboration and integration with NIH Commons / NHLBI Stage
* Challenges and opportunities from collaboration and integration with NIH Commons / NHLBI Stage
== Potential Population Genetics Update (15 minutes) ==
== Potential Population Genetics Update (20 minutes) ==
'' Check with Sebastian Zoellner''
'' Check with Sebastian Zoellner''
== Cloud access to TOPMed sequence data (20 minutes) ==
''Tom Blackwell to take the lead on this section''
[[Media:nhlbi.4768.fusera.slides.01.pdf|'''(slides)''']]
* NCBI's 'Fusera' controlled access mechanism
* User perspective -- involves a Google or Amazon billing project
* What is needed for users to have a great overall experience?
* Education and training for users
== Lunch (70 minutes) ==
== ENCORE analysis server (20 minutes) ==
''Matthew Flickinger will present this section''
* Principle of operation
* Releases only aggregate data summaries
* Visualizations help to assess results
* Data sharing and collaboration tools
* Capability to re-run previous jobs with new data
* SAIGE analysis gives accurate results in case-control studies
* Usage statistics comparing last 12-months to previous 12-months
* Some highlights from user survey results
== Manuscript support (30 minutes) ==
== Manuscript support (30 minutes) ==
* Context specific mutation rates
* Context specific mutation rates
* Data sharing with Centers for Common Disease Genetics
* Data sharing with Centers for Common Disease Genetics
== Interactions with outside groups (30 minutes) ==
== Interactions with outside groups (30 minutes) ==
* NIMH Parkinsons Disease Consortium
* NIMH Parkinsons Disease Consortium
== Cloud access to TOPMed sequence data (15 minutes) ==
== Break (20 minutes) ==
== Future plans for the next Task Order (30 minutes) ==
== Feedback from NHLBI (40 minutes) ==
== Feedback from NHLBI (60 minutes) ==
== Finish (3:50 pm) ==
