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Normalization involves reducing representations of a variant to a canonical representation. Normalization can be applied to biallelic variants or multiallelic variants. The problem of normalization is solvable and there exists a unique representation that is left aligned and parsimonious. Mathematical proof is published. [http://bioinformatics.oxfordjournals.org/content/early/2015/03/22/bioinformatics.btv112]
Normalization involves reducing representations of a variant to a canonical representation. Normalization can be applied to biallelic variants or multiallelic variants. The problem of normalization is solvable and there exists a unique representation that is left aligned and parsimonious. Mathematical proof is published. [http://bioinformatics.oxfordjournals.org/content/suppl/2015/02/19/btv112.DC1/VtNormApplicationNote_supp_20141113_1346.pdf]
[http://bioinformatics.oxfordjournals.org/content/31/13/2202 Adrian Tan, Gonçalo R. Abecasis and Hyun Min Kang. (2015) Unified Representation of Genetic Variants. Bioinformatics.]
[http://bioinformatics.oxfordjournals.org/content/31/13/2202 Adrian Tan, Gonçalo R. Abecasis and Hyun Min Kang. (2015) Unified Representation of Genetic Variants. Bioinformatics.]
= Translations =
A mandarin translation can be found [http://www.lyon0804.com/fan-yi-variant-normalization.html here]
= Maintained by =
= Maintained by =
This page is maintained by [mailto:atks@umich.edu Adrian].
This page is maintained by [mailto:atks@umich.edu Adrian].
