Biostatistics 666: Linkage Disequilibrium
Introduce the concept of linkage disequilibrium. Provide students with an understanding of D' and r2, the two most common measures of linkage disequilibrium, and the forces that shape them. Provide several illustrations of the extent of linkage disequilibrium in the genome, including the idea that the extent of linkage disequilibrium will vary between populations and genomic regions.
Introduce the concept of SNP-tagging and its consequences for association studies, both positive (because it implies that powerful studies don't have to examine all variants) and negative (because it makes identification of causal variants more challenging).
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