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RAREMETAL METHOD

367 bytes added, 23:12, 8 April 2014
SKAT META ANALYSIS
===SKAT META ANALYSIS===
SKAT has been powerful detecting genes with rare variants having opposite directions in effect sizes. Meta-analysis statistic can also be re-constructed using single variant meta-analysis scores and their covariances <math>\mathbf{Q}=\mathbf{{U_{meta}}^T}\mathbf{W}\mathbf{U_{meta}}</math>.  As shown in Wu et. al, the null distribution of the <math> \mathbf{Q} </math> statistic follows a mixture chi-sqaured distribution described as  
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