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, 23:12, 8 April 2014
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| ===SKAT META ANALYSIS=== | | ===SKAT META ANALYSIS=== |
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− | <math>\mathbf{Q}=\mathbf{{U_{meta}}^T}\mathbf{W}\mathbf{U_{meta}}</math> | + | SKAT has been powerful detecting genes with rare variants having opposite directions in effect sizes. Meta-analysis statistic can also be re-constructed using single variant meta-analysis scores and their covariances |
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| + | <math>\mathbf{Q}=\mathbf{{U_{meta}}^T}\mathbf{W}\mathbf{U_{meta}}</math>. |
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| + | As shown in Wu et. al, the null distribution of the <math> \mathbf{Q} </math> statistic follows a mixture chi-sqaured distribution described as |
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