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# Changes

From Genome Analysis Wiki

→SKAT META ANALYSIS

SKAT is most powerful when detecting genes with rare variants having opposite directions in effect sizes. Meta-analysis statistic can also be re-constructed using single variant meta-analysis scores and their covariances

<math>\mathbf{Q}=\mathbf{{U_{meta}}^T}\mathbf{W}\mathbf{U_{meta}}</math>, where <math>\mathbf{W}</math> is the diagonal matrix of weights of rare variants included in a gene.

As shown in [http://www.ncbi.nlm.nih.gov/pubmed/21737059 '''Wu et. al'''], the null distribution of the <math> \mathbf{Q} </math> statistic follows a mixture chi-sqaured distribution described as