# Changes

,  22:47, 8 April 2014
Line 46: Line 46:
$T_{VT}=\max(T_{b\left(f_1\right)},T_{b\left(f_2\right)},\dots,T_{b\left(f_m\right)})$

$T_{VT}=\max(T_{b\left(f_1\right)},T_{b\left(f_2\right)},\dots,T_{b\left(f_m\right)})$
−
where the burden test statistic under any allele frequency threshold can be constructed from single variant meta-analysis statistics
+
where the burden test statistic under any allele frequency threshold can be constructed from single variant meta-analysis statistics using

$T_{b\left(f_j\right)}=\boldsymbol{\phi}_{f_j}^\mathbf{T}\sum_{i=1}^n{\mathbf{U_i}}\bigg/\sqrt{\boldsymbol{\phi}_{f_j}^\mathbf{T}\left(\sum_{i=1}^n{\mathbf{V_i}}\right)\boldsymbol{\phi}_{f_j}}$

$T_{b\left(f_j\right)}=\boldsymbol{\phi}_{f_j}^\mathbf{T}\sum_{i=1}^n{\mathbf{U_i}}\bigg/\sqrt{\boldsymbol{\phi}_{f_j}^\mathbf{T}\left(\sum_{i=1}^n{\mathbf{V_i}}\right)\boldsymbol{\phi}_{f_j}}$
−
where $j$ represents any allele frequency in a group of rare variants.
+
where $j$ represents any allele frequency in a group of rare variants, $\boldsymbol{\phi}_{f_j}$ is a

===SKAT META ANALYSIS===

===SKAT META ANALYSIS===
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