Biostatistics 666: Introduction to De Novo Assembly

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Overview

Introduces the issues surrounding de novo assembly of complex genomes, with a particular focus on issues related to variant discovery. Also provides a brief overview of the results of Lander and Waterman on contig length.

Slides

Slides in PDF Format

Recommended Reading

Iqbal Z, Caccamo M, Turner I, Flicek P, McVean G (2012) De novo assembly and genotyping of variants using colored de Bruijn graphs. Nature Genetics 44:226-232

Lander E and Waterman M (1988) Genomic mapping by fingerprinting random clones: a mathematical analysis. Genomics 2:231-239

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