Changes

== Modeling Relatedness ==

== Modeling Relatedness ==

we use a variance component model to handle familial relationships.In a sample of n individuals, we model the observed phenotype vector (y) as a sum of covariate effects (specified by a design matrix X and a vector of covariate effects β), additive genetic effects (modeled in vector g) and non-shared environmental effects (modeled in vector ε). Thus:

we use a variance component model to handle familial relationships.In a sample of n individuals, we model the observed phenotype vector (y) as a sum of covariate effects (specified by a design matrix X and a vector of covariate effects β), additive genetic effects (modeled in vector g) and non-shared environmental effects (modeled in vector ε). Thus:

   y=xβ+g+ε

   <math>y\ =\ X\ \Beta</math>

== Single Variant Score Tests ==

== Single Variant Score Tests ==