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, 13:46, 10 March 2014
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| == Modeling Relatedness == | | == Modeling Relatedness == |
− | we use a variance component model to handle familial relationships. | + | we use a variance component model to handle familial relationships.In a sample of n individuals, we model the observed phenotype vector (y) as a sum of covariate effects (specified by a design matrix X and a vector of covariate effects β), additive genetic effects (modeled in vector g) and non-shared environmental effects (modeled in vector ε). Thus: |
| + | y=xβ+g+ε |
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| == Single Variant Score Tests == | | == Single Variant Score Tests == |