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Revision as of 23:07, 8 September 2010
, 23:07, 8 September 2010→Proportion of dbSNPs
== Proportion of dbSNPs ==
== Proportion of dbSNPs ==
Most of the genetic variants in any one individual have been previously observed in other individuals. Thus, it is usually a good diagnostic to investigate what fraction of variants in an individual genome have been previously described in [[www.ncbi.nlm.nih.gov/projects/SNP/ dbSNP]].
Most of the genetic variants in any one individual have been previously observed in other individuals. Thus, it is usually a good diagnostic to investigate what fraction of variants in an individual genome have been previously described in [http://www.ncbi.nlm.nih.gov/projects/SNP/ dbSNP].
The expected proportion of previously discovered SNPs (those already catalogued in dbSNP) and novel SNPs (those that haven't been previously discovered) will change overtime. The dbSNP database is being constantly updated so that currently (mid-2010) we'd expect >90% of the variants in an individual genome to have been previously discovered.
The expected proportion of previously discovered SNPs (those already catalogued in dbSNP) and novel SNPs (those that haven't been previously discovered) will change overtime. The dbSNP database is being constantly updated so that currently (mid-2010) we'd expect >90% of the variants in an individual genome to have been previously discovered.
