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Once all input files have been processed, simply issue the <code>ANALYZE</code> command to execute a meta-analysis. If you'd like to execute interim analysis that include only a subset of the studies, issue the ANALYZE command after the corresponding input files have been processed.
Once all input files have been processed, simply issue the <code>ANALYZE</code> command to execute a meta-analysis. If you'd like to execute interim analysis that include only a subset of the studies, issue the ANALYZE command after the corresponding input files have been processed.
ANALYZE
To allow for heterogeneity, use the <code>ANALYZE HETEROGENEITY</code> command. This command will take a little longer to run, because it requires each input file to be examined twice. The METAL heterogeneity analysis requires a second pass of analysis to decide whether observed effect sizes (or test statistics) are homogeneous across samples. The resulting heterogeneity statistic has n-1 degrees of freedom for n samples.
To allow for heterogeneity, use the <code>ANALYZE HETEROGENEITY</code> command. This command will take a little longer to run, because it requires each input file to be examined twice. The METAL heterogeneity analysis requires a second pass of analysis to decide whether observed effect sizes (or test statistics) are homogeneous across samples. The resulting heterogeneity statistic has n-1 degrees of freedom for n samples.
ANALYZE HETEROGENEITY
METAL does not require that all input files report a result for every marker. Any available data is used. To restrict the output to only markers that have at least a specific number of individuals analysed (or weight), use a command like the following:
METAL does not require that all input files report a result for every marker. Any available data is used. To restrict the output to only markers that have at least a specific number of individuals analysed (or weight), use a command like the following:
MINWEIGHT 10000
MINWEIGHT 10000
For example to restrict the output to show only Markers with at least 10,000 individuals.
For example to restrict the output to show only Markers with a total sample size of at least 10,000 individuals.
== Additional Analysis Options ==
== Additional Analysis Options ==
