# Biostatistics 666: Introduction to the E-M Algorithm

## Objective

Introduce the E-M algorithm in genetics, demonstrating applications to allele frequency estimation for recessive alleles and ABO blood group alleles. After the lecture, students should start to develop an intuition for how the E-M algorithm handles missing data.

## Slides

## Recommended Reading

Slatkin M, Excoffier L (1996) Testing for linkage disequilibrium in genotypic data using the EM algorithm. *Heredity* **76**:377–383