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Biostatistics 666: Introduction to the E-M Algorithm

Objective

Introduce the E-M algorithm in genetics, demonstrating applications to allele frequency estimation for recessive alleles and ABO blood group alleles. After the lecture, students should start to develop an intuition for how the E-M algorithm handles missing data.

Slides

Recommended Reading

Slatkin M, Excoffier L (1996) Testing for linkage disequilibrium in genotypic data using the EM algorithm. Heredity 76:377–383