Biostatistics 666: Introduction to the E-M Algorithm
Introduce the E-M algorithm in genetics, demonstrating applications to allele frequency estimation for recessive alleles and ABO blood group alleles. After the lecture, students should start to develop an intuition for how the E-M algorithm handles missing data.
Slatkin M, Excoffier L (1996) Testing for linkage disequilibrium in genotypic data using the EM algorithm. Heredity 76:377–383