Difference between revisions of "Biostatistics 666: Linkage Tests for Pairs of Individuals"
From Genome Analysis Wiki
Jump to navigationJump to search (Created page with '== Overview == This lecture introduces simple linkage tests in the context of affected sibling pairs. One test, originally described by Bishop and Williamson (1990) focuses on i…') |
|||
| (2 intermediate revisions by the same user not shown) | |||
| Line 3: | Line 3: | ||
This lecture introduces simple linkage tests in the context of affected sibling pairs. One test, originally described by Bishop and Williamson (1990) focuses on identity-by-state sharing. A more refined test, introduced by Risch (1990), models IBD information using a likelihood approach. | This lecture introduces simple linkage tests in the context of affected sibling pairs. One test, originally described by Bishop and Williamson (1990) focuses on identity-by-state sharing. A more refined test, introduced by Risch (1990), models IBD information using a likelihood approach. | ||
| − | == Lecture Notes == | + | == Lecture Notes == |
| − | [[Media:666. | + | [[Media:666.14.pdf|Slides in PDF Format]] |
== Recommended Reading == | == Recommended Reading == | ||
| − | Bishop DT and Williamson JA (1990)''Am J Hum Genet'' '''46''':254-265 | + | Bishop DT and Williamson JA (1990) ''Am J Hum Genet'' '''46''':254-265 |
| − | Risch (1990) | + | Risch (1990) ''Am J Hum Genet'' '''46''':242-253 |
Latest revision as of 10:37, 26 May 2010
Overview
This lecture introduces simple linkage tests in the context of affected sibling pairs. One test, originally described by Bishop and Williamson (1990) focuses on identity-by-state sharing. A more refined test, introduced by Risch (1990), models IBD information using a likelihood approach.
Lecture Notes
Recommended Reading
Bishop DT and Williamson JA (1990) Am J Hum Genet 46:254-265
Risch (1990) Am J Hum Genet 46:242-253
