Difference between revisions of "Biostatistics 666: Linkage Tests for Pairs of Individuals"
From Genome Analysis Wiki
Jump to navigationJump to search| Line 3: | Line 3: | ||
This lecture introduces simple linkage tests in the context of affected sibling pairs. One test, originally described by Bishop and Williamson (1990) focuses on identity-by-state sharing. A more refined test, introduced by Risch (1990), models IBD information using a likelihood approach. | This lecture introduces simple linkage tests in the context of affected sibling pairs. One test, originally described by Bishop and Williamson (1990) focuses on identity-by-state sharing. A more refined test, introduced by Risch (1990), models IBD information using a likelihood approach. | ||
| − | == Lecture Notes == | + | == Lecture Notes == |
| − | [[Media:666. | + | [[Media:666.14.pdf|Slides in PDF Format]] |
== Recommended Reading == | == Recommended Reading == | ||
Latest revision as of 10:37, 26 May 2010
Overview
This lecture introduces simple linkage tests in the context of affected sibling pairs. One test, originally described by Bishop and Williamson (1990) focuses on identity-by-state sharing. A more refined test, introduced by Risch (1990), models IBD information using a likelihood approach.
Lecture Notes
Recommended Reading
Bishop DT and Williamson JA (1990) Am J Hum Genet 46:254-265
Risch (1990) Am J Hum Genet 46:242-253
